{"id":46048,"date":"2022-10-13T12:46:28","date_gmt":"2022-10-13T10:46:28","guid":{"rendered":"https:\/\/RevistaEspa\u00f1olaNaturopatia.naturopatiadigital.eu\/?p=46048"},"modified":"2022-10-13T12:46:28","modified_gmt":"2022-10-13T10:46:28","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-curcumina-como-terapia-adjunta-y-modulador-de-microarn-en-el-cancer-de-mama","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=46048","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina como terapia adjunta y modulador de microARN en el c\u00e1ncer de mama\u00bb"},"content":{"rendered":"<p><img decoding=\"async\" class=\"size-full wp-image-46049 alignleft\" src=\"https:\/\/RevistaEspa\u00f1olaNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2022\/10\/Current_Pharmacewutical_Design.jpg\" alt=\"\" width=\"133\" height=\"172\" \/>Norouzi, S., Majeed, M., Pirro, M., Generali, D., &amp; Sahebkar, A. (2018). <a href=\"https:\/\/www.ingentaconnect.com\/content\/ben\/cpd\/2018\/00000024\/00000002\/art00008\">Curcumin as an adjunct therapy and microRNA modulator in breast cancer<\/a>.\u00a0<i>Current pharmaceutical design<\/i>,\u00a0<i>24<\/i>(2), 171-177.<\/p>\n<p><span>ANTECEDENTES: La patogenia del c\u00e1ncer de mama es paralela a distintas alteraciones en el perfil de expresi\u00f3n de varios microARN (miARN). Estudios recientes han demostrado que los miARN pueden servir como marcadores de diagn\u00f3stico y pron\u00f3stico, y tambi\u00e9n como dianas terap\u00e9uticas en el c\u00e1ncer de mama.\u00a0La curcumina es un polifenol diet\u00e9tico biol\u00f3gicamente activo que ha surgido con fuertes propiedades antitumorales que tambi\u00e9n est\u00e1n documentadas en el c\u00e1ncer de mama.<\/span><\/p>\n<p><span>METODOS: Se realiz\u00f3 una b\u00fasqueda electr\u00f3nica en varias bases de datos para proporcionar una descripci\u00f3n general de la curcumina como terapia complementaria y modulador de miARN en el c\u00e1ncer de mama y resaltar la importancia de las observaciones para el tratamiento de las terapias contra el c\u00e1ncer.<\/span><\/p>\n<p><span>RESULTADOS: Las supuestas propiedades antitumorales de la curcumina est\u00e1n mediadas por diversos mecanismos que incluyen la inhibici\u00f3n de la proliferaci\u00f3n celular, la met\u00e1stasis, la migraci\u00f3n, la invasi\u00f3n y la angiog\u00e9nesis, y la inducci\u00f3n de la detenci\u00f3n del ciclo celular G2\/M, la apoptosis y la paraptosis. La evidencia reciente implica que la curcumina puede interactuar con varios miARN oncog\u00e9nicos y supresores de tumores involucrados en diferentes etapas del c\u00e1ncer de mama.\u00a0En este contexto, se ha demostrado la regulaci\u00f3n positiva de miR181b, miR-34a, miR-16, miR-15a y miR-146b-5p, y la regulaci\u00f3n negativa de miR-19a y miR-19b despu\u00e9s del tratamiento de varios tipos de c\u00e1ncer de mama. l\u00edneas celulares con curcumina.\u00a0Estos efectos conducen a la supresi\u00f3n de la tumorig\u00e9nesis y la met\u00e1stasis, ya la inducci\u00f3n de la apoptosis.<\/span><\/p>\n<p><span>CONCLUSION: La curcumina aparece como un importante modulador de miARN en el c\u00e1ncer de mama. Sin embargo, se justifican m\u00e1s investigaciones para dilucidar el impacto de la curcumina en el perfil del transcriptoma de miARN del c\u00e1ncer de mama y el impacto resultante de los modelos experimentales.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Norouzi, S., Majeed, M., Pirro, M., Generali, D., &amp; Sahebkar, A. (2018). Curcumin as an adjunct therapy and microRNA modulator in breast cancer.\u00a0Current pharmaceutical design,\u00a024(2), 171-177. ANTECEDENTES: La patogenia del c\u00e1ncer de mama es paralela a distintas alteraciones en el perfil de expresi\u00f3n de varios microARN (miARN). Estudios recientes han demostrado que los miARN pueden [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-46048","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina como terapia adjunta y modulador de microARN en el c\u00e1ncer de mama&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=46048\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La curcumina como terapia adjunta y modulador de microARN en el c\u00e1ncer de mama&quot; -\" \/>\n<meta property=\"og:description\" content=\"Norouzi, S., Majeed, M., Pirro, M., Generali, D., &amp; Sahebkar, A. (2018). Curcumin as an adjunct therapy and microRNA modulator in breast cancer.\u00a0Current pharmaceutical design,\u00a024(2), 171-177. ANTECEDENTES: La patogenia del c\u00e1ncer de mama es paralela a distintas alteraciones en el perfil de expresi\u00f3n de varios microARN (miARN). Estudios recientes han demostrado que los miARN pueden [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=46048\" \/>\n<meta property=\"article:published_time\" content=\"2022-10-13T10:46:28+00:00\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=46048#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=46048\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina como terapia adjunta y modulador de microARN en el c\u00e1ncer de mama\u00bb\",\"datePublished\":\"2022-10-13T10:46:28+00:00\",\"dateModified\":\"2022-10-13T10:46:28+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=46048\"},\"wordCount\":387,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Sustancias Bioactivas\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=46048#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=46048\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=46048\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \\\"La curcumina como terapia adjunta y modulador de microARN en el c\u00e1ncer de mama\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2022-10-13T10:46:28+00:00\",\"dateModified\":\"2022-10-13T10:46:28+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=46048#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=46048\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=46048#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina como terapia adjunta y modulador de microARN en el c\u00e1ncer de mama\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La curcumina como terapia adjunta y modulador de microARN en el c\u00e1ncer de mama\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=46048","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La curcumina como terapia adjunta y modulador de microARN en el c\u00e1ncer de mama\" -","og_description":"Norouzi, S., Majeed, M., Pirro, M., Generali, D., &amp; Sahebkar, A. (2018). Curcumin as an adjunct therapy and microRNA modulator in breast cancer.\u00a0Current pharmaceutical design,\u00a024(2), 171-177. ANTECEDENTES: La patogenia del c\u00e1ncer de mama es paralela a distintas alteraciones en el perfil de expresi\u00f3n de varios microARN (miARN). Estudios recientes han demostrado que los miARN pueden [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=46048","article_published_time":"2022-10-13T10:46:28+00:00","author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"2 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=46048#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=46048"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina como terapia adjunta y modulador de microARN en el c\u00e1ncer de mama\u00bb","datePublished":"2022-10-13T10:46:28+00:00","dateModified":"2022-10-13T10:46:28+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=46048"},"wordCount":387,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Sustancias Bioactivas"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=46048#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=46048","url":"https:\/\/rina.naturopatiadigital.eu\/?p=46048","name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"La curcumina como terapia adjunta y modulador de microARN en el c\u00e1ncer de mama\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2022-10-13T10:46:28+00:00","dateModified":"2022-10-13T10:46:28+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=46048#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=46048"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=46048#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa curcumina como terapia adjunta y modulador de microARN en el c\u00e1ncer de mama\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/46048","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=46048"}],"version-history":[{"count":1,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/46048\/revisions"}],"predecessor-version":[{"id":46050,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/46048\/revisions\/46050"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=46048"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=46048"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=46048"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}