{"id":46089,"date":"2022-12-01T14:51:08","date_gmt":"2022-12-01T13:51:08","guid":{"rendered":"https:\/\/RevistaEspa\u00f1olaNaturopatia.naturopatiadigital.eu\/?p=46089"},"modified":"2022-12-01T14:51:08","modified_gmt":"2022-12-01T13:51:08","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-flavonoides-contra-la-tormenta-inflamatoria-inducida-por-sars-cov-2","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=46089","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abFlavonoides contra la tormenta inflamatoria inducida por SARS-CoV-2\u00bb"},"content":{"rendered":"<p><img decoding=\"async\" class=\"size-full wp-image-46090 alignleft\" src=\"https:\/\/RevistaEspa\u00f1olaNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2022\/12\/Biomedicine_Pharmacotherapy.gif\" alt=\"\" width=\"112\" height=\"150\" \/>Liskova, A., Samec, M., Koklesova, L., Samuel, S. M., Zhai, K., Al-Ishaq, R. K., &#8230; &amp; Kubatka, P. (2021). <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0753332221002158\">Flavonoids against the SARS-CoV-2 induced inflammatory storm<\/a>.\u00a0<i>Biomedicine &amp; Pharmacotherapy<\/i>,\u00a0<i>138<\/i>, 111430.<\/p>\n<p><span>La gravedad de la enfermedad de COVID-19, especialmente en ancianos y pacientes con comorbilidades, se caracteriza por\u00a0<\/span><span>hipercitocinemia\u00a0<\/span><span>, una respuesta inmunitaria exagerada asociada con una liberaci\u00f3n incontrolada y excesiva de mediadores de citoquinas proinflamatorias (tormenta de citoquinas).\u00a0<\/span><span>Los flavonoides<\/span><span>\u00a0, importantes metabolitos secundarios de las plantas, se han estudiado durante mucho tiempo como intervenciones terap\u00e9uticas en<\/span><span>\u00a0enfermedades inflamatorias\u00a0<\/span><span>debido a sus efectos moduladores de citoquinas.\u00a0<\/span><\/p>\n<p><span>En esta revisi\u00f3n, discutimos el papel potencial de los flavonoides en la modulaci\u00f3n de las v\u00edas de\u00a0<\/span><span>se\u00f1alizaci\u00f3n<\/span><span> que son cruciales para la enfermedad de COVID-19, particularmente aquellas relacionadas con la inflamaci\u00f3n y la inmunidad.\u00a0<\/span><\/p>\n<p><span>La capacidad inmunomoduladora de los flavonoides, llevada a cabo por la regulaci\u00f3n de\u00a0<\/span><span>mediadores inflamatorios<\/span><span>, la inhibici\u00f3n de la activaci\u00f3n endotelial,\u00a0<\/span><span>el inflamasoma NLRP3<\/span><span> , los receptores tipo toll (TLR) o la prote\u00edna 4 que contiene bromodominio (BRD4), y la activaci\u00f3n del factor 2 relacionado con el\u00a0<\/span><span>factor 2<\/span><span>(Nrf2), podr\u00edan ser beneficiosos en la regulaci\u00f3n de la tormenta de citocinas durante la infecci\u00f3n por SARS-CoV-2.\u00a0Adem\u00e1s, la capacidad de los flavonoides para inhibir la<\/span><span>\u00a0dipeptidil peptidasa 4<\/span><span>\u00a0(DPP4), neutralizar la proteasa<\/span><span>similar a la 3-quimotripsina(3CL<\/span><sup><span>pro<\/span><\/sup><span>) o afectar la<\/span><span>microbiota intestinal <\/span><span>para mantener la respuesta inmune, y la acci\u00f3n dual de la enzima convertidora de angiotensina 2 (ACE-2) tambi\u00e9n puede aplicarse potencialmente a las respuestas inflamatorias exageradas inducidas por el SARS-CoV-2.\u00a0<\/span><\/p>\n<p><span>Con base en los efectos previamente probados de los flavonoides en otras enfermedades o en la base de estudios recientemente publicados asociados con COVID-19 (bioinform\u00e1tica, acoplamiento molecular), es razonable suponer efectos positivos de los flavonoides en los cambios inflamatorios asociados con COVID-19.\u00a0Esta revisi\u00f3n destaca el estado actual del conocimiento sobre la utilidad de los flavonoides en el manejo de la COVID-19 y tambi\u00e9n apunta a los m\u00faltiples efectos biol\u00f3gicos de los flavonoides en las v\u00edas de se\u00f1alizaci\u00f3n asociadas a los procesos inflamatorios que se encuentran desregulados en la patolog\u00eda inducida por el SARS-CoV- 2.\u00a0<\/span><\/p>\n<p><span>La identificaci\u00f3n de los agentes,\u00a0incluyendo sustancias naturales como los flavonoides, representa un gran enfoque potencialmente utilizable en el manejo de COVID-19.\u00a0Aunque todav\u00eda no se ha investigado cl\u00ednicamente, la aplicabilidad de los flavonoides contra la COVID-19 podr\u00eda ser una estrategia prometedora debido al amplio espectro de sus actividades biol\u00f3gicas.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Liskova, A., Samec, M., Koklesova, L., Samuel, S. M., Zhai, K., Al-Ishaq, R. K., &#8230; &amp; Kubatka, P. (2021). Flavonoids against the SARS-CoV-2 induced inflammatory storm.\u00a0Biomedicine &amp; Pharmacotherapy,\u00a0138, 111430. La gravedad de la enfermedad de COVID-19, especialmente en ancianos y pacientes con comorbilidades, se caracteriza por\u00a0hipercitocinemia\u00a0, una respuesta inmunitaria exagerada asociada con una liberaci\u00f3n incontrolada [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-46089","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Flavonoides contra la tormenta inflamatoria inducida por SARS-CoV-2&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=46089\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Flavonoides contra la tormenta inflamatoria inducida por SARS-CoV-2&quot; -\" \/>\n<meta property=\"og:description\" content=\"Liskova, A., Samec, M., Koklesova, L., Samuel, S. M., Zhai, K., Al-Ishaq, R. K., &#8230; &amp; Kubatka, P. (2021). Flavonoids against the SARS-CoV-2 induced inflammatory storm.\u00a0Biomedicine &amp; Pharmacotherapy,\u00a0138, 111430. La gravedad de la enfermedad de COVID-19, especialmente en ancianos y pacientes con comorbilidades, se caracteriza por\u00a0hipercitocinemia\u00a0, una respuesta inmunitaria exagerada asociada con una liberaci\u00f3n incontrolada [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=46089\" \/>\n<meta property=\"article:published_time\" content=\"2022-12-01T13:51:08+00:00\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutos\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=46089#article\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=46089\"},\"author\":{\"name\":\"admin\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\"},\"headline\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abFlavonoides contra la tormenta inflamatoria inducida por SARS-CoV-2\u00bb\",\"datePublished\":\"2022-12-01T13:51:08+00:00\",\"dateModified\":\"2022-12-01T13:51:08+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=46089\"},\"wordCount\":436,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"articleSection\":[\"Sustancias Bioactivas\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=46089#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=46089\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?p=46089\",\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \\\"Flavonoides contra la tormenta inflamatoria inducida por SARS-CoV-2\\\" -\",\"isPartOf\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\"},\"datePublished\":\"2022-12-01T13:51:08+00:00\",\"dateModified\":\"2022-12-01T13:51:08+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=46089#breadcrumb\"},\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/rina.naturopatiadigital.eu\/?p=46089\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/?p=46089#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/rina.naturopatiadigital.eu\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abFlavonoides contra la tormenta inflamatoria inducida por SARS-CoV-2\u00bb\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#website\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"name\":\"\",\"description\":\"Red Investigaci\u00f3n Naturop\u00e1tica\",\"publisher\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"es\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#organization\",\"name\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\",\"url\":\"https:\/\/rina.naturopatiadigital.eu\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"contentUrl\":\"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg\",\"width\":960,\"height\":960,\"caption\":\"Organizaci\u00f3n Colegial Naturop\u00e1tica\"},\"image\":{\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7\",\"name\":\"admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"es\",\"@id\":\"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g\",\"caption\":\"admin\"},\"sameAs\":[\"https:\/\/rina.naturopatiadigital.eu\"],\"url\":\"https:\/\/rina.naturopatiadigital.eu\/?author=1\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Flavonoides contra la tormenta inflamatoria inducida por SARS-CoV-2\" -","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/rina.naturopatiadigital.eu\/?p=46089","og_locale":"es_ES","og_type":"article","og_title":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Flavonoides contra la tormenta inflamatoria inducida por SARS-CoV-2\" -","og_description":"Liskova, A., Samec, M., Koklesova, L., Samuel, S. M., Zhai, K., Al-Ishaq, R. K., &#8230; &amp; Kubatka, P. (2021). Flavonoids against the SARS-CoV-2 induced inflammatory storm.\u00a0Biomedicine &amp; Pharmacotherapy,\u00a0138, 111430. La gravedad de la enfermedad de COVID-19, especialmente en ancianos y pacientes con comorbilidades, se caracteriza por\u00a0hipercitocinemia\u00a0, una respuesta inmunitaria exagerada asociada con una liberaci\u00f3n incontrolada [&hellip;]","og_url":"https:\/\/rina.naturopatiadigital.eu\/?p=46089","article_published_time":"2022-12-01T13:51:08+00:00","author":"admin","twitter_card":"summary_large_image","twitter_misc":{"Escrito por":"admin","Tiempo de lectura":"3 minutos"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=46089#article","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=46089"},"author":{"name":"admin","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7"},"headline":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abFlavonoides contra la tormenta inflamatoria inducida por SARS-CoV-2\u00bb","datePublished":"2022-12-01T13:51:08+00:00","dateModified":"2022-12-01T13:51:08+00:00","mainEntityOfPage":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=46089"},"wordCount":436,"commentCount":0,"publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"articleSection":["Sustancias Bioactivas"],"inLanguage":"es","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/rina.naturopatiadigital.eu\/?p=46089#respond"]}]},{"@type":"WebPage","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=46089","url":"https:\/\/rina.naturopatiadigital.eu\/?p=46089","name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \"Flavonoides contra la tormenta inflamatoria inducida por SARS-CoV-2\" -","isPartOf":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#website"},"datePublished":"2022-12-01T13:51:08+00:00","dateModified":"2022-12-01T13:51:08+00:00","breadcrumb":{"@id":"https:\/\/rina.naturopatiadigital.eu\/?p=46089#breadcrumb"},"inLanguage":"es","potentialAction":[{"@type":"ReadAction","target":["https:\/\/rina.naturopatiadigital.eu\/?p=46089"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/rina.naturopatiadigital.eu\/?p=46089#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/rina.naturopatiadigital.eu\/"},{"@type":"ListItem","position":2,"name":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abFlavonoides contra la tormenta inflamatoria inducida por SARS-CoV-2\u00bb"}]},{"@type":"WebSite","@id":"https:\/\/rina.naturopatiadigital.eu\/#website","url":"https:\/\/rina.naturopatiadigital.eu\/","name":"","description":"Red Investigaci\u00f3n Naturop\u00e1tica","publisher":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/rina.naturopatiadigital.eu\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"es"},{"@type":"Organization","@id":"https:\/\/rina.naturopatiadigital.eu\/#organization","name":"Organizaci\u00f3n Colegial Naturop\u00e1tica","url":"https:\/\/rina.naturopatiadigital.eu\/","logo":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/","url":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","contentUrl":"https:\/\/RevistaEspa\u00f1oladeNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2020\/11\/logo2.jpg","width":960,"height":960,"caption":"Organizaci\u00f3n Colegial Naturop\u00e1tica"},"image":{"@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/432852c9ed996fc42e869a813ecbffd7","name":"admin","image":{"@type":"ImageObject","inLanguage":"es","@id":"https:\/\/rina.naturopatiadigital.eu\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/65efbf35ed30d944c0c1110a5f02b399a5ee3b1e80d2b081398ab064fe5cc0e4?s=96&d=mm&r=g","caption":"admin"},"sameAs":["https:\/\/rina.naturopatiadigital.eu"],"url":"https:\/\/rina.naturopatiadigital.eu\/?author=1"}]}},"_links":{"self":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/46089","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=46089"}],"version-history":[{"count":1,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/46089\/revisions"}],"predecessor-version":[{"id":46091,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=\/wp\/v2\/posts\/46089\/revisions\/46091"}],"wp:attachment":[{"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=46089"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=46089"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/rina.naturopatiadigital.eu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=46089"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}