{"id":46129,"date":"2023-01-18T12:18:14","date_gmt":"2023-01-18T11:18:14","guid":{"rendered":"https:\/\/RevistaEspa\u00f1olaNaturopatia.naturopatiadigital.eu\/?p=46129"},"modified":"2023-01-18T12:18:14","modified_gmt":"2023-01-18T11:18:14","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-silimarina-en-la-prevencion-y-tratamiento-de-enfermedades-hepaticas-y-cancer-primario-de-higado","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=46129","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abSilimarina en la prevenci\u00f3n y tratamiento de enfermedades hep\u00e1ticas y c\u00e1ncer primario de h\u00edgado\u00bb"},"content":{"rendered":"<p><img fetchpriority=\"high\" decoding=\"async\" class=\"size-medium wp-image-46130 alignleft\" src=\"https:\/\/RevistaEspa\u00f1olaNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2023\/01\/Current_Pharmaceutical-Biotechnology-233x300.jpg\" alt=\"\" width=\"233\" height=\"300\" srcset=\"https:\/\/rina.naturopatiadigital.eu\/wp-content\/uploads\/2023\/01\/Current_Pharmaceutical-Biotechnology-233x300.jpg 233w, https:\/\/rina.naturopatiadigital.eu\/wp-content\/uploads\/2023\/01\/Current_Pharmaceutical-Biotechnology-795x1024.jpg 795w, https:\/\/rina.naturopatiadigital.eu\/wp-content\/uploads\/2023\/01\/Current_Pharmaceutical-Biotechnology-768x989.jpg 768w, https:\/\/rina.naturopatiadigital.eu\/wp-content\/uploads\/2023\/01\/Current_Pharmaceutical-Biotechnology-1192x1536.jpg 1192w, https:\/\/rina.naturopatiadigital.eu\/wp-content\/uploads\/2023\/01\/Current_Pharmaceutical-Biotechnology-600x773.jpg 600w, https:\/\/rina.naturopatiadigital.eu\/wp-content\/uploads\/2023\/01\/Current_Pharmaceutical-Biotechnology.jpg 1231w\" sizes=\"(max-width: 233px) 100vw, 233px\" \/>Feh\u00e9r, J., &amp; Lengyel, G. (2012). <a href=\"https:\/\/web.archive.org\/web\/20190228160217id_\/http:\/\/pdfs.semanticscholar.org\/a5c9\/a91c85c0b19da115f9cb420844b3c0c35ee6.pdf\">Silymarin in the prevention and treatment of liver diseases and primary liver cancer<\/a>.\u00a0<i>Current pharmaceutical biotechnology<\/i>,\u00a0<i>13<\/i>(1), 210-217.<\/p>\n<p><span>En las enfermedades cr\u00f3nicas del h\u00edgado causadas por el estr\u00e9s oxidativo (enfermedades del h\u00edgado graso alcoh\u00f3lico y no alcoh\u00f3lico, toxicidad hep\u00e1tica inducida por f\u00e1rmacos y productos qu\u00edmicos), los medicamentos antioxidantes como la silimarina pueden tener un efecto beneficioso.\u00a0<\/span><span>La cirrosis hep\u00e1tica, el h\u00edgado graso no alcoh\u00f3lico y la esteatohepatitis son factores de riesgo para el carcinoma hepatocelular (CHC).\u00a0<\/span><span>La resistencia a la insulina y el estr\u00e9s oxidativo son los principales mecanismos patog\u00e9nicos que conducen a la lesi\u00f3n de las c\u00e9lulas hep\u00e1ticas en estos pacientes.\u00a0<\/span><\/p>\n<p><span>La silimarina ejerce actividad estabilizadora de membranas y antioxidante, promueve la regeneraci\u00f3n de hepatocitos;\u00a0<\/span><span>adem\u00e1s reduce la reacci\u00f3n inflamatoria e inhibe la fibrog\u00e9nesis en el h\u00edgado.\u00a0<\/span><span>Estos resultados han sido establecidos por ensayos experimentales y cl\u00ednicos.\u00a0<\/span><\/p>\n<p><span>Seg\u00fan estudios abiertos, la administraci\u00f3n a largo plazo de silimarina aument\u00f3 significativamente el tiempo de supervivencia de los pacientes con cirrosis hep\u00e1tica inducida por el alcohol.\u00a0<\/span><span>Seg\u00fan los resultados de los estudios que utilizan m\u00e9todos de biolog\u00eda molecular, la silimarina puede reducir significativamente la proliferaci\u00f3n de c\u00e9lulas tumorales, la angiog\u00e9nesis y la resistencia a la insulina.\u00a0<\/span><span>Adem\u00e1s, ejerce un efecto antiateroscler\u00f3tico y suprime la producci\u00f3n de prote\u00ednas inducida por el factor de necrosis tumoral alfa y la expresi\u00f3n de ARNm debido a las mol\u00e9culas de adhesi\u00f3n.\u00a0<\/span><\/p>\n<p><span>El efecto quimiopreventivo de la silimarina sobre el HCC se ha establecido en varios estudios que utilizan m\u00e9todos in vitro e in vivo;\u00a0<\/span><span>puede ejercer un efecto beneficioso sobre el equilibrio de la supervivencia celular y la apoptosis al interferir con las citocinas.\u00a0<\/span><span>Adem\u00e1s de esto,\u00a0<\/span><span>Tambi\u00e9n se ha detectado actividad antiinflamatoria y efecto inhibitorio de la silimarina sobre el desarrollo de met\u00e1stasis.\u00a0<\/span><span>En algunas enfermedades neopl\u00e1sicas, la silimarina tambi\u00e9n se puede administrar como terapia adyuvante.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Feh\u00e9r, J., &amp; Lengyel, G. (2012). Silymarin in the prevention and treatment of liver diseases and primary liver cancer.\u00a0Current pharmaceutical biotechnology,\u00a013(1), 210-217. En las enfermedades cr\u00f3nicas del h\u00edgado causadas por el estr\u00e9s oxidativo (enfermedades del h\u00edgado graso alcoh\u00f3lico y no alcoh\u00f3lico, toxicidad hep\u00e1tica inducida por f\u00e1rmacos y productos qu\u00edmicos), los medicamentos antioxidantes como la silimarina [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-46129","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Silimarina en la prevenci\u00f3n y tratamiento de enfermedades hep\u00e1ticas y c\u00e1ncer primario de h\u00edgado&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=46129\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Silimarina en la prevenci\u00f3n y tratamiento de enfermedades hep\u00e1ticas y c\u00e1ncer primario de h\u00edgado&quot; -\" \/>\n<meta property=\"og:description\" content=\"Feh\u00e9r, J., &amp; Lengyel, G. (2012). Silymarin in the prevention and treatment of liver diseases and primary liver cancer.\u00a0Current pharmaceutical biotechnology,\u00a013(1), 210-217. 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