{"id":46178,"date":"2023-08-16T15:43:34","date_gmt":"2023-08-16T13:43:34","guid":{"rendered":"https:\/\/RevistaEspa\u00f1olaNaturopatia.naturopatiadigital.eu\/?p=46178"},"modified":"2023-08-16T15:43:53","modified_gmt":"2023-08-16T13:43:53","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-piperina-producto-natural-alivia-la-encefalomielitis-alergica-experimental-en-ratones-al-actuar-sobre-la-dihidroorotato-desh","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=46178","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa piperina producto natural alivia la encefalomielitis al\u00e9rgica experimental en ratones al actuar sobre la dihidroorotato deshidrogenasa\u00bb"},"content":{"rendered":"<p><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-46041 alignleft\" src=\"https:\/\/RevistaEspa\u00f1olaNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2022\/09\/Biochemical_pharmacology.jpg\" alt=\"\" width=\"194\" height=\"259\" \/>Liu, Z., Hu, Q., Wang, W., Lu, S., Wu, D., Ze, S., &#8230; &amp; Huang, J. (2020). <a href=\"https:\/\/d197for5662m48.cloudfront.net\/documents\/publicationstatus\/30603\/preprint_pdf\/04c24a5dddd3eb95c5d9222909a66890.pdf\">Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase. <\/a><i>Biochemical Pharmacology<\/i>,\u00a0<i>177<\/i>, 114000.<\/p>\n<p>La esclerosis m\u00faltiple (EM) es la enfermedad inflamatoria cr\u00f3nica y debilitante m\u00e1s popular del sistema nervioso central (SNC) que sigue siendo incurable.\u00a0La dihidroorotato deshidrogenasa (DHODH) es fundamental para la actividad de los linfocitos T y representa un objetivo terap\u00e9utico potencial para la EM.<\/p>\n<p>Aqu\u00ed identificamos la piperina, un componente bioactivo de la pimienta negra, como un potente inhibidor de DHODH con un IC\u00a0<sub>50<\/sub>valor de 0,88 \u03bcM.\u00a0La calorimetr\u00eda de titulaci\u00f3n isot\u00e9rmica y el ensayo de termofluor demuestran la interacci\u00f3n directa entre piperina y DHODH.\u00a0La estructura cristalina cocompleja de DHODH y piperina a una resoluci\u00f3n de 1,98 \u00c5 revela adem\u00e1s que el residuo Tyr356 de DHODH es crucial para la uni\u00f3n de piperina.<\/p>\n<p>Es importante destacar que mostramos que la piperina puede inhibir la sobreactivaci\u00f3n de las c\u00e9lulas T de una manera dependiente de DHODH en el ensayo de c\u00e9lulas T activado por concanavalina A y el ensayo de reacci\u00f3n de linfocitos mixtos.\u00a0Finalmente, la piperina exhibe un fuerte efecto preventivo y terap\u00e9utico en la encefalomielitis al\u00e9rgica experimental (EAE) inducida por MOG, un modelo \u00fatil para estudiar tratamientos potenciales para la EM, al restringir la infiltraci\u00f3n de c\u00e9lulas inflamatorias en el SNC y prevenir la destrucci\u00f3n de la mielina y la barrera hematoencef\u00e1lica (BBB ) ruptura.<\/p>\n<p>En conjunto, estos resultados ponen de manifiesto que la DHODH es una diana terap\u00e9utica para las enfermedades autoinmunes del sistema nervioso y demuestran que la piperina desempe\u00f1a un papel novedoso en el tratamiento de la EM.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Liu, Z., Hu, Q., Wang, W., Lu, S., Wu, D., Ze, S., &#8230; &amp; Huang, J. (2020). Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase. Biochemical Pharmacology,\u00a0177, 114000. La esclerosis m\u00faltiple (EM) es la enfermedad inflamatoria cr\u00f3nica y debilitante m\u00e1s popular del sistema nervioso central (SNC) que sigue siendo incurable.\u00a0La [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-46178","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La piperina producto natural alivia la encefalomielitis al\u00e9rgica experimental en ratones al actuar sobre la dihidroorotato deshidrogenasa&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=46178\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La piperina producto natural alivia la encefalomielitis al\u00e9rgica experimental en ratones al actuar sobre la dihidroorotato deshidrogenasa&quot; -\" \/>\n<meta property=\"og:description\" content=\"Liu, Z., Hu, Q., Wang, W., Lu, S., Wu, D., Ze, S., &#8230; &amp; Huang, J. (2020). Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase. Biochemical Pharmacology,\u00a0177, 114000. 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