{"id":46240,"date":"2023-10-15T14:07:46","date_gmt":"2023-10-15T12:07:46","guid":{"rendered":"https:\/\/RevistaEspa\u00f1olaNaturopatia.naturopatiadigital.eu\/?p=46240"},"modified":"2023-10-15T14:07:46","modified_gmt":"2023-10-15T12:07:46","slug":"area-de-conocimiento-tecnologia-naturopatica-o-naturopatia-aplicada-modulo-naturopatia-alimentaria-trofologia-la-vitamina-c-previene-la-mutacion-del-adn-inducida-por-el-estres-o","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=46240","title":{"rendered":"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria \u2013 TROFOLOGIA: \u201cLa vitamina C previene la mutaci\u00f3n del ADN inducida por el estr\u00e9s oxidativo\u00bb"},"content":{"rendered":"<p><img fetchpriority=\"high\" decoding=\"async\" class=\"size-full wp-image-46241 alignleft\" src=\"https:\/\/RevistaEspa\u00f1olaNaturopatia.naturopatiadigital.eu\/wp-content\/uploads\/2023\/10\/Journal_Biological-Chemistry.gif\" alt=\"\" width=\"200\" height=\"259\" \/>Lutsenko, E. A., C\u00e1rcamo, J. M., &amp; Golde, D. W. (2002). <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0021925819607398\">Vitamin C prevents DNA mutation induced by oxidative stress.<\/a>\u00a0<i>Journal of Biological Chemistry<\/i>,\u00a0<i>277<\/i>(19), 16895-16899.<\/p>\n<p><span>El papel preciso de la vitamina C en la prevenci\u00f3n de mutaciones del ADN es controvertido.\u00a0Aunque el \u00e1cido asc\u00f3rbico tiene fuertes propiedades antioxidantes, tambi\u00e9n tiene efectos prooxidantes en presencia de metales de transici\u00f3n libres.\u00a0Recientemente se inform\u00f3 que la vitamina C induce la descomposici\u00f3n de hidroper\u00f3xidos lip\u00eddicos independientemente de las interacciones met\u00e1licas, lo que sugiere que puede causar da\u00f1o al ADN.\u00a0<\/span><\/p>\n<p><span>OBJETIVO. Para abordar directamente el papel de la vitamina C en el mantenimiento de la integridad gen\u00f3mica, desarrollamos un sistema gen\u00e9tico para cuantificar las mutaciones de la base de guanina inducidas en c\u00e9lulas humanas bajo estr\u00e9s oxidativo.\u00a0<\/span><\/p>\n<p><span>METODO. El ensayo utiliz\u00f3 una construcci\u00f3n de pl\u00e1smido que codifica el ADNc de cloranfenicol acetil transferasa modificado para contener un cod\u00f3n de parada de color \u00e1mbar, que se restaur\u00f3 al tipo salvaje mediante transversi\u00f3n de G a T inducida por estr\u00e9s oxidativo. La frecuencia de mutaci\u00f3n se determin\u00f3 a partir del n\u00famero de pl\u00e1smidos que conten\u00edan el gen de cloranfenicol acetil transferasa de tipo salvaje rescatados de c\u00e9lulas sometidas a estr\u00e9s oxidativo. Las c\u00e9lulas se cargaron con vitamina C exponi\u00e9ndolas al \u00e1cido deshidroasc\u00f3rbico, evitando as\u00ed los efectos prooxidantes del \u00e1cido asc\u00f3rbico relacionados con los metales de transici\u00f3n.\u00a0<\/span><\/p>\n<p><span>RESULTADOS. Encontramos que la carga de vitamina C result\u00f3 en una disminuci\u00f3n sustancial de las mutaciones inducidas por el H <\/span><sub><span>2<\/span><\/sub><span>\u00a0O\u00a0<\/span><sub><span>2<\/span><\/sub><span>\u00a0.\u00a0El agotamiento del glutati\u00f3n provoc\u00f3 citotoxicidad y un aumento en la frecuencia de mutaciones inducidas por H\u00a0<\/span><sub><span>2<\/span><\/sub><span>\u00a0O\u00a0<\/span><sub><span>2<\/span><\/sub><span>\u00a0;\u00a0sin embargo, la frecuencia de la mutaci\u00f3n disminuy\u00f3 notablemente en las c\u00e9lulas agotadas precargadas con vitamina C. Los resultados de la mutaci\u00f3n se correlacionaron con una disminuci\u00f3n en la 8-oxoguanina total medida en el ADN gen\u00f3mico de las c\u00e9lulas cargadas con vitamina C y sometidas a estr\u00e9s oxidativo.\u00a0<\/span><\/p>\n<p><span>CONCLUSION. Estos hallazgos respaldan directamente el concepto de que altas concentraciones intracelulares de vitamina C pueden prevenir mutaciones inducidas por la oxidaci\u00f3n en las c\u00e9lulas humanas.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Lutsenko, E. A., C\u00e1rcamo, J. M., &amp; Golde, D. W. (2002). Vitamin C prevents DNA mutation induced by oxidative stress.\u00a0Journal of Biological Chemistry,\u00a0277(19), 16895-16899. El papel preciso de la vitamina C en la prevenci\u00f3n de mutaciones del ADN es controvertido.\u00a0Aunque el \u00e1cido asc\u00f3rbico tiene fuertes propiedades antioxidantes, tambi\u00e9n tiene efectos prooxidantes en presencia de metales [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-46240","post","type-post","status-publish","format-standard","hentry","category-naturopatia-alimentaria-trofologia"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria \u2013 TROFOLOGIA: \u201cLa vitamina C previene la mutaci\u00f3n del ADN inducida por el estr\u00e9s oxidativo&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=46240\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria \u2013 TROFOLOGIA: \u201cLa vitamina C previene la mutaci\u00f3n del ADN inducida por el estr\u00e9s oxidativo&quot; -\" \/>\n<meta property=\"og:description\" content=\"Lutsenko, E. A., C\u00e1rcamo, J. M., &amp; Golde, D. W. (2002). Vitamin C prevents DNA mutation induced by oxidative stress.\u00a0Journal of Biological Chemistry,\u00a0277(19), 16895-16899. 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