{"id":46267,"date":"2023-12-08T14:59:52","date_gmt":"2023-12-08T13:59:52","guid":{"rendered":"https:\/\/RevistaEspa\u00f1olaNaturopatia.naturopatiadigital.eu\/?p=46267"},"modified":"2023-12-08T14:59:52","modified_gmt":"2023-12-08T13:59:52","slug":"area-de-conocimiento-tecnologia-naturopatica-o-naturopatia-aplicada-modulo-naturopatia-alimentaria-trofologia-cambios-en-las-proteinas-relacionadas-con-los-microtubulos-y-la-autofagia","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=46267","title":{"rendered":"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria \u2013 TROFOLOGIA: \u00abCambios en las prote\u00ednas relacionadas con los microt\u00fabulos y la autofagia en ratones con deficiencia de vitamina E a largo plazo\u00bb"},"content":{"rendered":"<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/d13i5xhouzkrd.cloudfront.net\/assets\/format-images\/7a55510f6a1d54fe6205b30d968735cf\/7a55510f6a1d54fe6205b30d968735cf-cover.jpg\" alt=\"Free Radical Research Template - Taylor and Francis\" width=\"271\" height=\"350\" \/>Fukui, K., Masuda, A., Hosono, A., Suwabe, R., Yamashita, K., Shinkai, T., &amp; Urano, S. (2014). <a href=\"https:\/\/www.tandfonline.com\/doi\/full\/10.3109\/10715762.2014.898295\">Changes in microtubule-related proteins and autophagy in long-term vitamin E-deficient mice<\/a>.\u00a0<i>Free Radical Research<\/i>,\u00a0<i>48<\/i>(6), 649-658.<\/p>\n<p><span>FONDO: La deficiencia de vitamina E induce disfunci\u00f3n neuronal y, si bien es probable que el estr\u00e9s oxidativo intervenga en la mediaci\u00f3n de este proceso, los mecanismos detallados a\u00fan no se han dilucidado. <\/span><span>Anteriormente, encontramos degeneraci\u00f3n axonal en la regi\u00f3n CA1 del hipocampo en ratones con deficiencia de vitamina E de 6 meses de edad (a largo plazo).\u00a0<\/span><span>Sin embargo, los ratones con deficiencia de vitamina E de 3 meses de edad (a corto plazo) no mostraron degeneraci\u00f3n axonal en la misma regi\u00f3n.\u00a0<\/span><\/p>\n<p><span>METODO: Para caracterizar los mecanismos implicados en la degeneraci\u00f3n axonal en ratones con deficiencia prolongada de vitamina E, examinamos los cambios en las prote\u00ednas relacionadas con los microt\u00fabulos. <\/span><\/p>\n<p><span>RESULTADOS: La deficiencia de vitamina E a largo plazo condujo a un aumento significativo de la expresi\u00f3n de la forma fosforilada de la prote\u00edna mediadora de la respuesta a la colapsina (CRMP) -2 en comparaci\u00f3n con la deficiencia a corto plazo. <\/span><span>Es bien sabido que CRMP-2 desempe\u00f1a un papel crucial en el mantenimiento de la funci\u00f3n de las neuritas.\u00a0<\/span><span>De manera similar, la deficiencia de vitamina E a largo plazo disminuy\u00f3 significativamente la expresi\u00f3n del ARNm de regulaci\u00f3n silenciosa de la informaci\u00f3n del tipo de apareamiento (SIRT) -2 en comparaci\u00f3n con la deficiencia a corto plazo.\u00a0<\/span><span>SIRT-2 pertenece a una familia de histonas desacetilasas de clase III (HDAC) y funciona en la desacetilaci\u00f3n de tubulinas.\u00a0<\/span><span>Adem\u00e1s, la expresi\u00f3n de la cadena ligera de la prote\u00edna asociada a los microt\u00fabulos (MAP-LC) 3-2, que es una prote\u00edna clave de la autofagia, fue significativamente mayor en la deficiencia de vitamina E a corto plazo que en la deficiencia a largo plazo.\u00a0<\/span><\/p>\n<p><span>CONCLUSION: Estos resultados indican que los mecanismos de lesi\u00f3n axonal en ratones con deficiencia de vitamina E a largo plazo est\u00e1n relacionados con la disfunci\u00f3n en el ensamblaje de los microt\u00fabulos a trav\u00e9s de alteraciones en las prote\u00ednas relacionadas con los microt\u00fabulos y la autofagia.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Fukui, K., Masuda, A., Hosono, A., Suwabe, R., Yamashita, K., Shinkai, T., &amp; Urano, S. (2014). Changes in microtubule-related proteins and autophagy in long-term vitamin E-deficient mice.\u00a0Free Radical Research,\u00a048(6), 649-658. FONDO: La deficiencia de vitamina E induce disfunci\u00f3n neuronal y, si bien es probable que el estr\u00e9s oxidativo intervenga en la mediaci\u00f3n de este proceso, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-46267","post","type-post","status-publish","format-standard","hentry","category-naturopatia-alimentaria-trofologia"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria \u2013 TROFOLOGIA: &quot;Cambios en las prote\u00ednas relacionadas con los microt\u00fabulos y la autofagia en ratones con deficiencia de vitamina E a largo plazo&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=46267\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Tecnolog\u00eda Naturop\u00e1tica o Naturopat\u00eda Aplicada: M\u00f3dulo: Naturopat\u00eda Alimentaria \u2013 TROFOLOGIA: &quot;Cambios en las prote\u00ednas relacionadas con los microt\u00fabulos y la autofagia en ratones con deficiencia de vitamina E a largo plazo&quot; -\" \/>\n<meta property=\"og:description\" content=\"Fukui, K., Masuda, A., Hosono, A., Suwabe, R., Yamashita, K., Shinkai, T., &amp; Urano, S. (2014). Changes in microtubule-related proteins and autophagy in long-term vitamin E-deficient mice.\u00a0Free Radical Research,\u00a048(6), 649-658. FONDO: La deficiencia de vitamina E induce disfunci\u00f3n neuronal y, si bien es probable que el estr\u00e9s oxidativo intervenga en la mediaci\u00f3n de este proceso, [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=46267\" \/>\n<meta property=\"article:published_time\" content=\"2023-12-08T13:59:52+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/d13i5xhouzkrd.cloudfront.net\/assets\/format-images\/7a55510f6a1d54fe6205b30d968735cf\/7a55510f6a1d54fe6205b30d968735cf-cover.jpg\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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