{"id":46304,"date":"2024-01-24T13:27:03","date_gmt":"2024-01-24T12:27:03","guid":{"rendered":"https:\/\/RevistaEspa\u00f1olaNaturopatia.naturopatiadigital.eu\/?p=46304"},"modified":"2024-01-24T13:27:03","modified_gmt":"2024-01-24T12:27:03","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-la-naringina-mejora-la-toxicidad-mitocondrial-inducida-por-los-inhibidores-de-la-transcriptasa-inversa-nucleosidos-del-vih-1","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=46304","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abLa naringina mejora la toxicidad mitocondrial inducida por los inhibidores de la transcriptasa inversa nucle\u00f3sidos del VIH-1\u00bb"},"content":{"rendered":"<p><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/www.ingentaconnect.com\/images\/journal-logos\/ben\/chr.png\" alt=\"logo\" width=\"142\" height=\"183\" \/>Oluwafeyisetan, A., Olubunmi, A., &amp; Peter, O. (2016). <a href=\"https:\/\/www.ingentaconnect.com\/content\/ben\/chr\/2016\/00000014\/00000006\/art00009\">Naringin ameliorates HIV-1 nucleoside reverse transcriptase inhibitors-induced mitochondrial toxicity<\/a>.\u00a0<i>Current HIV Research<\/i>,\u00a0<i>14<\/i>(6), 506-516.<\/p>\n<p><span><strong>ANTECEDENTES<\/strong>:\u00a0 La generaci\u00f3n de especies reactivas de ox\u00edgeno (ROS) mitocondriales y la fosforilaci\u00f3n oxidativa defectuosa (OXPHOS) se han propuesto como posibles mecanismos subyacentes al desarrollo de toxicidades mitocondriales inducidas por inhibidores nucle\u00f3sidos de la transcriptasa inversa (INTI). Las opciones disponibles para el manejo de estas complicaciones han producido, hasta ahora, resultados controvertidos, por lo que se necesita m\u00e1s investigaci\u00f3n sobre agentes m\u00e1s nuevos y prometedores.\u00a0Anteriormente se han demostrado los efectos antioxidantes y eliminadores de radicales libres de la naringina, un flavonoide de origen vegetal.<\/span><\/p>\n<p><span><strong>OBJETIVO<\/strong>: Este estudio fue dise\u00f1ado para investigar los efectos de la naringina sobre la toxicidad mitocondrial inducida por NRTI.<\/span><\/p>\n<p><span>\u00a0<strong>METODOS<\/strong>: Las ratas Wistar se dividieron aleatoriamente en zidovudina (AZT) \u00fanicamente (100 mg\/kg de peso corporal BW); AZT+naringina (100+50 mg\/kg peso corporal);\u00a0AZT+Vitamina E (100+100 mg\/kg peso corporal);\u00a0Estavudina (d4T): \u00fanicamente (50 mg\/kg de peso corporal);\u00a0d4T+naringina (50+50 mg\/kg peso corporal);\u00a0Grupos tratados con d4T + vitamina E (50+100 mg\/kg BW) y veh\u00edculo (3,0 ml\/kg BW), respectivamente.\u00a0Despu\u00e9s de 56 d\u00edas de dosificaci\u00f3n oral diaria, las ratas fueron sacrificadas mediante sobredosis de halotano, se extrajo sangre mediante punci\u00f3n card\u00edaca y se extirparon r\u00e1pidamente los h\u00edgados para realizar m\u00e1s an\u00e1lisis bioqu\u00edmicos y ultraestructurales.<\/span><\/p>\n<p><span><strong>RESULTADOS<\/strong>: AZT o d4T solo causaron disfunci\u00f3n mitocondrial significativa y da\u00f1o ultraestructural mitocondrial en comparaci\u00f3n con los controles, mientras que la naringina o la vitamina E revirtieron los \u00edndices de disfunci\u00f3n mitocondrial evidenciada por una reducci\u00f3n significativa de las concentraciones de malondialdeh\u00eddo mitocondrial (MDA) y de lactato en sangre, y un aumento de la super\u00f3xido dismutasa de manganeso en el h\u00edgado. (MnSOD) y expresi\u00f3n regulada positiva de la subunidad codificada mitocondrial de la prote\u00edna del complejo IV de la cadena de transporte de electrones (ETC) en comparaci\u00f3n con ratas tratadas solo con AZT o d4T. Adem\u00e1s, la naringina o la vitamina E, respectivamente, mejoraron el da\u00f1o mitocondrial observado en ratas tratadas solo con AZT o d4T.<\/span><\/p>\n<p><span><strong>CONCLUSION<\/strong>: La naringina mejor\u00f3 el estr\u00e9s oxidativo y el da\u00f1o mitocondrial inducido por NRTI y, por lo tanto, podr\u00eda ser beneficiosa en el manejo de las toxicidades y complicaciones derivadas del uso de NRTI.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oluwafeyisetan, A., Olubunmi, A., &amp; Peter, O. (2016). Naringin ameliorates HIV-1 nucleoside reverse transcriptase inhibitors-induced mitochondrial toxicity.\u00a0Current HIV Research,\u00a014(6), 506-516. ANTECEDENTES:\u00a0 La generaci\u00f3n de especies reactivas de ox\u00edgeno (ROS) mitocondriales y la fosforilaci\u00f3n oxidativa defectuosa (OXPHOS) se han propuesto como posibles mecanismos subyacentes al desarrollo de toxicidades mitocondriales inducidas por inhibidores nucle\u00f3sidos de la transcriptasa [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-46304","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La naringina mejora la toxicidad mitocondrial inducida por los inhibidores de la transcriptasa inversa nucle\u00f3sidos del VIH-1&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=46304\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;La naringina mejora la toxicidad mitocondrial inducida por los inhibidores de la transcriptasa inversa nucle\u00f3sidos del VIH-1&quot; -\" \/>\n<meta property=\"og:description\" content=\"Oluwafeyisetan, A., Olubunmi, A., &amp; Peter, O. (2016). Naringin ameliorates HIV-1 nucleoside reverse transcriptase inhibitors-induced mitochondrial toxicity.\u00a0Current HIV Research,\u00a014(6), 506-516. 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