{"id":46351,"date":"2024-06-04T12:26:22","date_gmt":"2024-06-04T10:26:22","guid":{"rendered":"https:\/\/RevistaEspa\u00f1olaNaturopatia.naturopatiadigital.eu\/?p=46351"},"modified":"2024-07-04T12:32:30","modified_gmt":"2024-07-04T10:32:30","slug":"area-de-conocimiento-naturopatia-descriptiva-el-acido-biliar-litocolico-mata-selectivamente-las-celulas-del-neuroblastoma-mientras-que-preserva-las-celulas-neuronales-normales","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=46351","title":{"rendered":"Area de Conocimiento: Naturopat\u00eda Descriptiva: \u00abEl \u00e1cido biliar litoc\u00f3lico mata selectivamente las c\u00e9lulas del neuroblastoma, mientras que preserva las c\u00e9lulas neuronales normales\u00bb"},"content":{"rendered":"<p><img fetchpriority=\"high\" decoding=\"async\" class=\"alignleft\" src=\"https:\/\/www.oncotarget.com\/public\/journals\/1\/cover_issue_520_en_US.png\" alt=\"Cover for Oncotarget Issue V15N1\" width=\"296\" height=\"383\" \/>Goldberg, A. A., Beach, A., Davies, G. F., Harkness, T. A., LeBlanc, A., &amp; Titorenko, V. I. (2011). <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3248158\/\">Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells<\/a>. <i>Oncotarget<\/i>,\u00a0<i>2<\/i>(10), 761.<\/p>\n<p>El envejecimiento es uno de los principales factores de riesgo del c\u00e1ncer. La aparici\u00f3n del c\u00e1ncer se puede posponer mediante intervenciones farmacol\u00f3gicas y diet\u00e9ticas contra el envejecimiento.<\/p>\n<p>Recientemente hemos descubierto en modelos celulares de levadura del envejecimiento que el \u00e1cido litoc\u00f3lico (LCA) prolonga la longevidad.<\/p>\n<p>Aqu\u00ed demostramos que, en concentraciones que no son citot\u00f3xicas para cultivos primarios de neuronas humanas, el LCA mata las l\u00edneas celulares de neuroblastoma (NB) BE(2)-m17, SK-n-SH, SK-n-MCIXC y Lan-1.<\/p>\n<p>En las c\u00e9lulas BE(2)-m17, SK-n-SH y SK-n-MCIXC, el efecto antitumoral del LCA se debe a la muerte celular apopt\u00f3tica. Por el contrario, la muerte de las c\u00e9lulas Lan-1 provocada por el LCA no es causada por apoptosis. Aunque las concentraciones bajas de LCA sensibilizan a las c\u00e9lulas BE(2)-m17 y SK-n-MCIXC a la muerte celular apopt\u00f3tica inducida por per\u00f3xido de hidr\u00f3geno controlada por las mitocondrias, estas concentraciones de LCA hacen que los cultivos primarios de neuronas humanas sean resistentes a esa forma de muerte celular.<\/p>\n<p>El LCA mata las l\u00edneas celulares BE(2)-m17 y SK-n-MCIXC al activar no solo la v\u00eda intr\u00ednseca (mitocondrial) de muerte celular apopt\u00f3tica impulsada por la permeabilizaci\u00f3n de la membrana externa mitocondrial y la activaci\u00f3n de la caspasa-9 iniciadora, sino tambi\u00e9n la v\u00eda extr\u00ednseca (receptor de muerte) de la apoptosis que implica la activaci\u00f3n de la caspasa-8 iniciadora.<\/p>\n<p>Con base en estos datos, proponemos un mecanismo subyacente a un efecto antitumoral potente y selectivo del LCA en c\u00e9lulas de NB humanas cultivadas. Adem\u00e1s, nuestro hallazgo de que el LCA mata c\u00e9lulas de c\u00e1ncer de mama humano cultivadas y de glioma de rata implica que tiene un amplio efecto antitumoral en c\u00e9lulas cancerosas derivadas de diferentes tejidos y organismos.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Goldberg, A. A., Beach, A., Davies, G. F., Harkness, T. A., LeBlanc, A., &amp; Titorenko, V. I. (2011). Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget,\u00a02(10), 761. El envejecimiento es uno de los principales factores de riesgo del c\u00e1ncer. La aparici\u00f3n del c\u00e1ncer se puede posponer mediante intervenciones farmacol\u00f3gicas y [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-46351","post","type-post","status-publish","format-standard","hentry","category-naturopatia-descriptiva"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Area de Conocimiento: Naturopat\u00eda Descriptiva: &quot;El \u00e1cido biliar litoc\u00f3lico mata selectivamente las c\u00e9lulas del neuroblastoma, mientras que preserva las c\u00e9lulas neuronales normales&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=46351\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Area de Conocimiento: Naturopat\u00eda Descriptiva: &quot;El \u00e1cido biliar litoc\u00f3lico mata selectivamente las c\u00e9lulas del neuroblastoma, mientras que preserva las c\u00e9lulas neuronales normales&quot; -\" \/>\n<meta property=\"og:description\" content=\"Goldberg, A. A., Beach, A., Davies, G. F., Harkness, T. A., LeBlanc, A., &amp; Titorenko, V. I. (2011). Lithocholic bile acid selectively kills neuroblastoma cells, while sparing normal neuronal cells. Oncotarget,\u00a02(10), 761. El envejecimiento es uno de los principales factores de riesgo del c\u00e1ncer. La aparici\u00f3n del c\u00e1ncer se puede posponer mediante intervenciones farmacol\u00f3gicas y [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=46351\" \/>\n<meta property=\"article:published_time\" content=\"2024-06-04T10:26:22+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-04T10:32:30+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.oncotarget.com\/public\/journals\/1\/cover_issue_520_en_US.png\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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