{"id":46364,"date":"2024-07-23T14:33:29","date_gmt":"2024-07-23T12:33:29","guid":{"rendered":"https:\/\/RevistaEspa\u00f1olaNaturopatia.naturopatiadigital.eu\/?p=46364"},"modified":"2024-07-23T14:43:26","modified_gmt":"2024-07-23T12:43:26","slug":"area-de-conocimiento-naturopatia-experimental-sustancias-bioactivas-nueva-estrategia-para-el-tratamiento-de-la-encefalitis-japonesa-utilizando-arctigenina-un-lignano-vegetal","status":"publish","type":"post","link":"https:\/\/rina.naturopatiadigital.eu\/?p=46364","title":{"rendered":"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: \u00abNueva estrategia para el tratamiento de la encefalitis japonesa utilizando arctigenina, un lignano vegetal\u00bb"},"content":{"rendered":"<p><img decoding=\"async\" class=\"alignleft\" src=\"https:\/\/upload.wikimedia.org\/wikipedia\/en\/4\/42\/J_of_Antimicrob_Chemo_cover.gif\" alt=\"Journal of Antimicrobial Chemotherapy - Wikipedia\" width=\"175\" height=\"226\" \/>Swarup, V., Ghosh, J., Mishra, M. K., &amp; Basu, A. (2008). <a href=\"https:\/\/academic.oup.com\/jac\/article\/61\/3\/679\/724527?login=false\">Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan<\/a>.\u00a0<i>Journal of Antimicrobial Chemotherapy<\/i>,\u00a0<i>61<\/i>(3), 679-688.<\/p>\n<div class=\" sec\">\n<p class=\"title\"><strong>Objetivos<\/strong>. Evaluar la eficacia terap\u00e9utica de la arctigenina en un modelo experimental de encefalitis japonesa (EJ).<\/p>\n<\/div>\n<div class=\"title\">\n<p><strong>M\u00e9todos<\/strong>.\u00a0Se infectaron por v\u00eda intravenosa ratones BALB\/c de cuatro a cinco semanas de edad, de ambos sexos, con una dosis letal de 3 \u00d7 10\u00a0<sup>5<\/sup>\u00a0pfu del virus de la encefalitis japonesa (VEJ). Al noveno d\u00eda de la infecci\u00f3n, todos los animales no tratados sucumbieron a la infecci\u00f3n. La arctigenina se disolvi\u00f3 en DMSO a una concentraci\u00f3n de 0,5 mg\/ml y se almacen\u00f3 a 4 \u00b0C. Un d\u00eda despu\u00e9s de la inoculaci\u00f3n del virus, se administr\u00f3 arctigenina a los animales por v\u00eda intraperitoneal, dos veces al d\u00eda (10 mg\/kg de peso corporal) durante los siguientes 7 d\u00edas.<\/p>\n<\/div>\n<div class=\"title\"><strong>Resultados.<\/strong>\u00a0El tratamiento con arctigenina proporcion\u00f3 una protecci\u00f3n completa contra la encefalitis japonesa experimental. El efecto neuroprotector de la arctigenina se asoci\u00f3 con una marcada disminuci\u00f3n de: (i) la carga viral; (ii) la actividad de la caspasa-3 activa; (iii) las especies reactivas de ox\u00edgeno y las especies reactivas de nitr\u00f3geno; (iv) la microgliosis y las citocinas proinflamatorias; (v) los niveles de mol\u00e9culas de se\u00f1alizaci\u00f3n asociadas al estr\u00e9s; y (vi) la muerte neuronal. Adem\u00e1s, el tratamiento con arctigenina tambi\u00e9n mejora el resultado conductual despu\u00e9s de la encefalitis japonesa.<\/div>\n<p><strong>Conclusiones.<\/strong> En conclusi\u00f3n, nuestros hallazgos brindan una nueva perspectiva mecanicista sobre las acciones de la arctigenina en la encefalitis japonesa. Los resultados de nuestros experimentos\u00a0<em>in vivo<\/em>\u00a0e\u00a0<em>in vitro<\/em> indican claramente que la arctigenina redujo (i) la carga viral y la replicaci\u00f3n viral dentro del cerebro, (ii) la muerte neuronal y (iii) la inflamaci\u00f3n secundaria y el estr\u00e9s oxidativo resultante de la activaci\u00f3n de la microglia, lo que sugiere su potencial para tratar la encefalitis japonesa. Los efectos antivirales, neuroprotectores, desinflamatorios y antioxidantes de la arctigenina redujeron con \u00e9xito la gravedad de la enfermedad inducida por el virus de la encefalitis japonesa.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Swarup, V., Ghosh, J., Mishra, M. K., &amp; Basu, A. (2008). Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan.\u00a0Journal of Antimicrobial Chemotherapy,\u00a061(3), 679-688. Objetivos. Evaluar la eficacia terap\u00e9utica de la arctigenina en un modelo experimental de encefalitis japonesa (EJ). M\u00e9todos.\u00a0Se infectaron por v\u00eda intravenosa ratones BALB\/c de cuatro a cinco semanas [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-46364","post","type-post","status-publish","format-standard","hentry","category-sustancias-bioactivas"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v21.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Nueva estrategia para el tratamiento de la encefalitis japonesa utilizando arctigenina, un lignano vegetal&quot; -<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/rina.naturopatiadigital.eu\/?p=46364\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u00c1rea de conocimiento: Naturopat\u00eda Experimental: Sustancias Bioactivas: &quot;Nueva estrategia para el tratamiento de la encefalitis japonesa utilizando arctigenina, un lignano vegetal&quot; -\" \/>\n<meta property=\"og:description\" content=\"Swarup, V., Ghosh, J., Mishra, M. K., &amp; Basu, A. (2008). Novel strategy for treatment of Japanese encephalitis using arctigenin, a plant lignan.\u00a0Journal of Antimicrobial Chemotherapy,\u00a061(3), 679-688. Objetivos. Evaluar la eficacia terap\u00e9utica de la arctigenina en un modelo experimental de encefalitis japonesa (EJ). M\u00e9todos.\u00a0Se infectaron por v\u00eda intravenosa ratones BALB\/c de cuatro a cinco semanas [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/rina.naturopatiadigital.eu\/?p=46364\" \/>\n<meta property=\"article:published_time\" content=\"2024-07-23T12:33:29+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-07-23T12:43:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/upload.wikimedia.org\/wikipedia\/en\/4\/42\/J_of_Antimicrob_Chemo_cover.gif\" \/>\n<meta name=\"author\" content=\"admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutos\" \/>\n<script type=\"application\/ld+json\" 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